Product Information

The SampleSense Clinical system is uniquely optimized for high-throughput micro-sampling, positive confirmation of sample introduction, and stable performance for the analysis of difficult clinical sample matrices such as whole blood. Sample analysis rates of 180 blood lead samples per hour are demonstrated with longterm reproducibility within 1% RSD.

The SampleSense Clinical system is uniquely optimized for high-throughput micro-sampling, positive confirmation of sample introduction, and stable performance for the analysis of difficult clinical sample matrices. Sample analysis rates of > 180 blood lead samples per hour are demonstrated with long-term reproducibility of 1% RSD.

This work demonstrates the use of the prepFAST IC as the front-end sample introduction system for analyzing undiluted blood, serum, plasma, and urine. The undiluted biological samples are loaded by vacuum or syringe, depending on the matrix and the amount of sample available. For total metals analysis, each sample type is automatically diluted inline by an appropriate dilution factor. Urine may also be automatically analyzed in speciation mode to determine the arsenic species present in the sample. The automated features of the system allow for multiple methods to be queued and run unattended, resulting in more efficient use of the ICPMS.

Trace element analysis is vital for industrial, government, and academic communities. Knowing the total concentration of an element in a given sample is important, but it does not tell the whole story. The chemical species (e.g., As(III), As(V), or AsCH5O3) plays an important part in understanding how it can affect the environment, its bioavailability, or its toxicity. For example, inorganic arsenic (As(III)) is more toxic than organic arsenic (monomethylarsonic acid, MMA), whereas organic mercury (methylmercury) is more toxic than its inorganic form (Hg(II)).

SampleSense FAST is the most recent advancement in FAST technology. SampleSense couples an autosampler with an inert valve having integrated optical sensors to automatically detect the presence of a non-segmented liquid sample. Upon detection, the sensed sample is injected to the ICPMS nebulizer and the ICPMS analysis is triggered. Sample throughput is improved, sample consumption per analysis is reduced, and errors otherwise caused by empty sample tubes or missing sample tubes are eliminated.

Biomonitoring and clinical testing are important for improving human health. These tests help public health officials or medical doctors monitor the levels of essential elements and assess exposure to toxic or potentially toxic elements within the human body. While a great deal of work has been published on biomonitoring and clinical analyses, the majority of the work has been performed with manual sample preparation. This work will explore the use of two different automation platforms for clinical analyses, one for high-throughput sampling of manually prepared blood samples and the second an inline whole blood preparation method with micro-volume sampling. The comparison and validation of these systems was carried out by analyzing 2019 New York Department of Health Proficiency Testing samples that had known reference ranges for the analytes of interest (Cd, Hg, Mn, Se, and Pb). In addition, the ICP-MS methods were calibrated using two different matrix options, purchased base blood and