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Scientific Publications

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A combined approach to evaluate total phosphorus/inorganic phosphate levels in plants

Year: 2022
Products: SC-4 DX autosampler
Authors: Ma, B;Liu, Y;Li, X;Fang, Z;Zhang, L;He, Z;
Application: Biological;Total;
Inorganic phosphate (Pi) and phosphorus (P) homeostasis are essential for plant growth and yield, and reliable detection of dynamic Pi/P in different tissues is important for studying their biological functions. Here, we report a combined protocol for rapid determination of Pi/P levels. We first perform 31P NMR assay to reveal the intracellular Pi distribution and then dissect the level of Pi/P by the chromogenic reaction and ICP-MS analysis. Finally, we take μXRF element fluorescence assay to achieve the visual P distribution. For complete details on the use and execution of this protocol, please refer to Ma et al. (2021)....

A Comprehensive Approach to Understanding p66Shc Mitochondrial Function in Cardiovascular Health

Year: 2022
Products: 96-well plate reader
Authors: Haslem, LH;
Application: Clinical;Species;
p66Shc governs outcomes for many pathologies, including endothelial dysfunction, coronary artery disease (CAD), and ischemia/reperfusion injuries (IRI). During cardiovascular insults, p66Shc exacerbates reactive oxygen species (ROS) accumulation, which increases pro-apoptotic responses and worsens clinical outcomes. IRI clinical severity is coupled tight enough to p66Shc expression and ROS activity that p66Shc acts as a biomarker for CAD and IRIs. Inhibiting p66Shcmediated ROS accumulation therefore has high therapeutic potential in cardiovascular pathology. Others have shown that p66Shc ROS function is coupled to an unclear interaction with cytochrome c (cyt c) that increases either superoxide anion radical or H2O2 measurements. This has generated confusion about whether p66Shc produces radical or non-radical ROS, an important physiological distinction. Our findings resolve these discrepancies by identifying a previously unknown p66Shc function that describes how p66Shc causes H2O2 ac...

A multi-isotope and modelling approach for constraining hydro-connectivity in the East African Rift System, southern Ethiopia

Year: 2022
Products: prepFAST-MC™ system
Authors: Markowska, M;Martin, A;Vonhof, H;Guinoiseau, D;Fischer, M;Zinaye, B;Galer, S;Asrat, A;Junginger, A;
Application: isotope;
During the last African Humid Period (AHP; 15-5 ka), many lakes in the East African Rift System (EARS) experienced pronounced lake-level variations that dramatically transformed the hydrological landscape. Currently dry, saline or marshy-wetland terminal lakes became vast waterbodies, interconnected via overflow sills resulting in the formation of a several thousand-kilometre-long chain of lakes in the EARS. A quantitative, process-based understanding of these hydrological systems can advance our interpretation of past hydroclimate variability from proxy records. Here, we provide a critical modern hydrological dataset for the data-sparse Lake Chew Bahir basin in southern Ethiopia. Driven by modern data, an isotope-enabled hydro-balance model was developed to assess how increases in rainfall modulate δ18O and 87Sr/86Sr variability. Considering a terminal Lake Chew Bahir scenario, humid conditions resulted in higher lake δ18O (∼+14‰) due to increased evaporation and longer water re...

A natural uORF variant confers phosphorus acquisition diversity in soybean

Year: 2022
Products: CryoCell
Authors: Guo, Z;Cao, H;Zhao, J;Bai, S;Peng, W;Li, J;Sun, L;Chen, L;Lin, Z;Shi, C;Yang, Q;Yang, Y;Wang, X;Tian, J;Chen, Z;Liao, H;
Application: Cells;Tissue;
Phosphorus (P) is an essential element for all organisms. Because P fertilizers are a non-renewable resource and high fixation in soils, sustainable agriculture requires researchers to improve crop P acquisition efficiency. Here, we report a strong association signal at a locus of CPU1 (component of phosphorus uptake 1), from a genome-wide association study of P acquisition efficiency in a soybean core collection grown in the field. A SEC12-like gene, GmPHF1, is identified as the causal gene for CPU1. GmPHF1 facilitates the ER (endoplasmic reticulum) exit of the phosphate transporter, GmPT4, to the plasma membrane of root epidermal cells. A common SNP in an upstream open reading frame (uORF) of GmPHF1, which alters the abundance of GmPHF1 in a tissue-specific manner, contributes to P acquisition diversity in soybean. A natural genetic variation conditions diversity in soybean P acquisition, which can be used to develop P-efficient soybean genotypes....

A new solid target design for the production of 89Zr and radiosynthesis of high molar activity [89Zr]Zr-DBN

Year: 2022
Products: Elemental Scientific Inc. (ESI) SC2-DX autosamplers
Authors: Pandey, MK;Bansal, A;Ellinghuysen, JR;Vail, DJ;Berg, HM;DeGrado, TR;
Application: Cells;
Due to the advent of various biologics like antibodies, proteins, cells, viruses, and extracellular vesicles as biomarkers for disease diagnosis, progression, and as therapeutics, there exists a need to have a simple and ready to use radiolabeling synthon to enable noninvasive imaging trafficking studies. Previously, we reported [89Zr]zirconium-p-isothiocyanatobenzyl-desferrioxamine ([89Zr]Zr-DBN) as a synthon for the radiolabeling of biologics to allow PET imaging of cell trafficking. In this study, we focused on improving the molar activity (Am) of [89Zr]Zr-DBN, by enhancing 89Zr production on a low-energy cyclotron and developing a new reverse phase HPLC method to purify [89Zr]Zr-DBN. To enhance 89Zr production, a new solid target was designed, and production yield was optimized by varying, thickness of yttrium foil, beam current, irradiation duration and proton beam energy. After optimization, 4.78±0.33 GBq (129.3±8.9 mCi) of 89Zr was produced at 40 µA for 180 min (3 h) proton i...

A novel approach for adapting the standard addition method to single particle-ICP-MS for the accurate determination of NP size and number concentration in complex matrices

Year: 2022
Products: T piece
Authors: Aramendía, M;García-Mesa, J;Alonso, E;Garde, R;Bazo, A;Resano, J;Resano, M;
Application: ~
This paper presents a novel approach, based on the standard addition method, for overcoming the matrix effects that often hamper the accurate characterization of nanoparticles (NPs) in complex samples via single particle inductively coupled plasma mass spectrometry (SP-ICP-MS). In this approach, calibration of the particle size is performed by two different methods: (i) by spiking a suspension of NPs standards of known size containing the analyte, or (ii) by spiking the sample with ionic standards; either way, the measured sensitivity is used in combination with the transport efficiency (TE) for sizing the NPs. Moreover, such transport efficiency can be readily obtained from the data obtained via both calibration methods mentioned above, so that the particle number concentration can also be determined. The addition of both ionic and NP standards can be performed on-line, by using a T-piece with two inlet lines of different dimensions. The smaller of the two is used for the standards, t...

A precise and accurate analytical method for determination of osmium isotope ratios at the 1-15 pg level by using a MC-ICP-MS equipped with sparging introduction and high-sensitivity discrete dynode-type ion-counting detectors

Year: 2022
Products: SSI Quartz Dual Cyclonic Spray Chamber
Authors: Ohta, J;Nozaki, T;Sato, H;Ashida, K;Kato, Y;
Application: isotope;
Properly calibrated discrete dynode SEM ion-counting detectors and minimization of blank Os by an improved vial-cleaning method enables Os isotope analysis at the 1-15 pg level with high accuracy and precision....

A Quantitative Method for Determining Uptake of Silica Nanoparticles in Macrophages by Single Particle Inductively Coupled Plasma-Mass Spectrometry

Year: 2022
Products: 96-well ICP-MS microtiter plate
Authors: Rogers, KL;Cruz-Hernandez, A;Brown, JM;
Application: Cells;Biological;Environmental;Food;nanoparticle;
Engineered nanomaterials are becoming increasingly ubiquitous in our society, with numerous applications in medicine, consumer products, bioremediation, and advanced materials. As these nanomaterials increase in variety, analyzing their characteristics is of great importance. Single particle inductively coupled plasma-mass spectrometry (SP-ICP-MS) is a high-throughput, sensitive, and robust instrumental analysis method used to simultaneously characterize and quantify nanoparticles in a variety of matrices. One such type of nanoparticle of interest is amorphous silica nanoparticles (SiNPs). SiNPs have widespread use in consumer products such as food and cosmetics and are prime candidates for novel medical applications and uses in environmental bioremediation. Despite their increased use, SiNPs have been shown to have toxicological properties in vitro and in vivo, particularly with regard to the immune system. Because of the potential for increased SiNP exposure in the general public and...

A rapid method of simultaneous chromatographic purification of Li and Mg for isotopic analyses using MC-ICP-MS

Year: 2022
Products: Product Unavailable
Authors: Zhang, W;Tanaka, R;Kitagawa, H;Bohlin, M;Nakamura, E;
Application: isotope;
Lithium (Li) and Magnesium (Mg) isotopes have been widely used as valuable tracers to study geological processes. In general, several column separation procedures have been used to separate Li and Mg. In this study, we present an optimized protocol for the rapid and simultaneous purification of Li and Mg, which significantly reduces the separation time, required reagent volume, and procedural blanks compared to previous methods. Samples with small amounts of Li (generally 5 ng Li yielding Mg masses of 1-1200 μg) were separated, with the corresponding yields of Li and Mg being nearly 100%....

A Refinement of the Processes Controlling Dissolved Copper and Nickel Biogeochemistry: Insights From the Pan‐Arctic

Year: 2022
Products: SeaFAST
Authors: Jensen, L;Cullen, J;Jackson, S;Gerringa, L;Bauch, D;Middag, R;Sherrell, R;Fitzsimmons, J;
Application: Biological;Dissolved;isotope;
Recent studies, including many from the GEOTRACES program, have expanded our knowledge of trace metals in the Arctic Ocean, an isolated ocean dominated by continental shelf and riverine inputs. Here, we report a unique, pan-Arctic linear relationship between dissolved copper (Cu) and nickel (Ni) present north of 60°N that is absent in other oceans. The correlation is driven primarily by high Cu and Ni concentrations in the low salinity, river-influenced surface Arctic and low, homogeneous concentrations in Arctic deep waters, opposing their typical global distributions. Rivers are a major source of both metals, which is most evident within the central Arctic's Transpolar Drift. Local decoupling of the linear Cu-Ni relationship along the Chukchi Shelf and within the Canada Basin upper halocline reveals that Ni is additionally modified by biological cycling and shelf sediment processes, while Cu is mostly sourced from riverine inputs and influenced by mixing. This observation highlights...

A strontium isoscape of inland southeastern Australia

Year: 2022
Products: PrepFAST
Authors: de Caritat, P;Dosseto, A;Dux, F;
Application: Environmental;Dissolved;soil;isotope;
. The values and distribution patterns of the strontium (Sr) isotope ratio 87Sr / 86Sr in Earth surface materials is of use in the geological, environmental and social sciences. Ultimately, the 87Sr / 86Sr ratio of soil and everything that lives in and on it is inherited from the rock that is its parent material. In Australia, there are few large-scale surveys of 87Sr / 86Sr available, and here we report on a new, low-density dataset using 112 catchment outlet (floodplain) sediment samples covering 529,000 km2 of inland southeastern Australia (South Australia, New South Wales, Victoria). The coarse (< 2 mm) fraction of bottom sediment samples (depth ~0.6-0.8 m) from the National Geochemical Survey of Australia were milled and fully digested before Sr separation by chromatography and 87Sr / 86Sr determination by multicollector-inductively coupled plasma-mass spectrometry. The results show a wide range of 87Sr / 86Sr values from a minimum of 0.7089 to a maximum of 0.7511 (range 0.0422...

A total consumption infrared heated sample introduction system for nanoparticle measurement using single particle inductively coupled plasma mass spectrometry

Year: 2022
Products: Spray chamber
Authors: Zhou, Z;Al Hejami, A;Burgener, M;Burgener, J;Beauchemin, D;
Application: Total;nanoparticle;
A compact infrared-heated sample introduction system provides essentially 100% transport efficiency for single particle inductively coupled plasma mass spectrometry....

A triple threat: Ocean warming, acidification, and rare earth elements exposure triggers a superior antioxidant response and pigment production in the adaptable Ulva rigida

Year: 2022
Products: SeaFAST
Authors: Figueiredo, C;Grilo, T;Oliveira, R;Ferreira, I;Gil, F;Lopes, C;Brito, P;Ré, P;Caetano, M;Diniz, M;Raimundo, J;
Application: Total;seawater;
Anthropogenic increased atmospheric CO2 concentrations will lead to a drop of 0.4 units of seawater pH and ocean warming up to 4.8°C by 2100. Contaminant's toxicity is known to increase under a climate change scenario. Rare earth elements (REE) are emerging contaminants, that until now have no regulation regarding maximum concentration and discharge into the environment and have become vital to new technologies such as electric and hybrid-electric vehicle batteries, wind turbine generators and low-energy lighting. Studies of REE, namely Lanthanum (La) and Gadolinium (Gd), bioaccumulation, elimination, and toxicity in a multi-stressor environment (e.g., warming and acidification) are lacking. Hence, we investigated the algae phytoremediation capacity, the ecotoxicological responses and total chlorophyll and carotenoid contents in Ulva rigida during 7 days of co-exposure to La or Gd (15 µg L−1 or 10 µg L−1, respectively), and warming and acidification. Additionally, we assessed th...

Accumulation of molybdenum in major organs following repeated oral administration of bis-choline tetrathiomolybdate in the Sprague Dawley rat

Year: 2022
Products: imageBIO266 laser ablation system
Authors: Foster, JR;Billimoria, K;Del Castillo Busto, ME;Strekopytov, S;Goenaga-Infante, H;Morley, TJ;
Application: Clinical;Tissue;Laser;
Molybdenum is an essential dietary trace element required for several critical enzyme systems. High intake is associated with toxicity in ruminants and animal studies. The proposed therapeutic use of molybdenum based drugs poses a potential risk for accumulation through chronic administration of therapeutic doses of this element. The current experiment was designed to study the effect of daily dosing of a molybdenum compound, bis-choline tetrathiomolybdate (TTM), in Sprague Dawley rats using laser ablation inductively coupled plasma time-of-flight mass spectrometry (LA-ICP-ToF-MS), and two dosing levels of TTM for up to 3-months. To investigate if molybdenum accumulation was associated with tissue toxicity, histopathology, haematology and clinical biochemistry markers of toxicity were incorporated into the study design. There were no behavioural signs of toxicity to the rats, and no clinical or anatomic pathology associated with treatment. The current data did show a progressive accumu...

Additive-Free Aqueous Extraction of Copper and Zinc from Sulfidic Tailings Using Fast Microwave-Assisted Pre- and Post-Treatments

Year: 2022
Products: Elemental Scientific prepFAST autosampler
Authors: Kalebic, D;Dehaen, W;Spooren, J;
Application: Environmental;
Due to an ever-increasing demand for commodity and technology metals, secondary resources can complement the primary resource supply. Sulfidic mining waste from the Neves-Corvo mine (Portugal) is a pyrite-rich tailing that still contains valuable metals (Cu, Zn) and minor amounts of technology metals (Co, Mn) in the form of sulfides. In this work, by fine-tuning a fast microwave (MW)-assisted oxidative roasting process (5 min, 550 °C), the sulfide minerals containing the desired metals converted to water-soluble sulfate phases, whereas pyrite converted to water-insoluble magnetite and hematite. The desired metals Cu (76%) and Zn (46%), as well as Co (66%) and Mn (53%), could thus be selectively leached over Fe (2.9%) in water (25 °C, 30 min). The obtained leachates were further purified by selectively precipitating Fe (95%) and As (100%) by a MW-assisted hydrothermal treatment (150 °C, 1 h), leaving Cu, Zn, Mn, and Co in solution for further recovery. In the proposed three-step meth...

Administration of Silver Nasal Spray Leads to Nanoparticle Accumulation in Rat Brain Tissues

Year: 2022
Products: automatic sampler
Authors: Liu, N;Li, Y;Liu, L;Liu, X;Yin, Y;Qu, G;Shi, J;Song, M;He, B;Hu, L;Jiang, G;
Application: nanoparticle;
The use of commercial products containing engineered nanomaterials in realistic scenarios may lead to the accumulation of exogenous particles in brain tissues. In this study, we simulated the use of silver (Ag) nasal spray in humans using Sprague-Dawley rats at 0.04 mg/kg/day. Silver-containing particles were explicitly identified in the rat brain after the administration of nasal sprays containing colloidal Ag or silver ions (Ag+) for 2 weeks using multiple methods. The accumulation of Ag-containing particles showed a delayed effect in different brain regions of the rats, with the mass concentration of particles increasing continuously for 1-2 weeks after the termination of administration. The size of the observed Ag-containing particles extracted from the brain tissues ranged from 18.3 to 120.4 nm. Further characterization by high-resolution transmission electron microscopy with energy-dispersive spectroscopy showed that the nanoparticles comprised both Ag and sulfur (S), with Ag/S a...

Aerosol dilution for the introduction of complex matrix samples in plasma-based spectrometry techniques: a tutorial review

Year: 2022
Products: PC3
Authors: Duyck, C;Alves Peixoto, R;Rocha, A;Guilhermond de Souza Severino, H;Oliveira, P;Damasceno, R;Lorençatto, R;
Application: organic solvents;
Aerosol dilution (AD) is a sample introduction tool that allows the direct analysis of complex matrix samples by plasma-based analytical techniques....

Age features and reference intervals for the concentrations of some essential and toxic elements in laying hens

Year: 2022
Products: ESI SC-2 DX4 autosampler
Authors: Lebedev, S;Zavyalov, O;Frolov, AA;
Application: ~
Micronutrient imbalances pose a severe threat to the health and productivity of livestock and poultry. In this regard, a further stage in feeding science development will control and optimize the intake of mineral substances, including determining the elemental composition in some biosubstrates. One of these biosubstrates can be a feather. However, the amount of available information on the content of trace elements in laying hens is limited, complicating the laboratory data interpretation. Therefore, this study established reference intervals for the concentrations of the main essential and toxic elements in laying hens in different periods of ontogenesis.The study was conducted on clinically healthy Hisex Brown laying hens at the age of 10 (n=150), 30 (n=150), 120 (n=150), 150 (n=150), and 210 (n=150) days. All examined birds were born and raised on the territory of the South Ural biogeochemical province of Russia. The sampling of feathers was carried out by plucking the flight feath...

An eclogitic component in the Pitcairn mantle plume: Evidence from olivine compositions and Fe isotopes of basalts

Year: 2022
Products: ESI 50 μL min−1 PFA MicroFlow Teflon nebulizer
Authors: Shi, J;Zeng, G;Chen, L;Hanyu, T;Wang, X;Zhong, Y;Xie, L;Xie, W;
Application: isotope;
Subducted oceanic crust can transform into eclogite in the upper mantle, and generate chemical heterogeneity of mantle plumes, as recorded by elemental and radiogenic isotopic variations in oceanic island basalts (OIBs). The secondary pyroxenite produced by the reaction between eclogite-derived melt and peridotite is increasingly regarded as a major source component of OIBs, as well as peridotite. However, it remains unclear whether eclogite can be a direct source component of OIBs. To test this possibility, we present high-precision whole-rock Fe isotopes and the chemical compositions of olivine phenocrysts from well-characterized EM1-type basalts from Pitcairn Island. The Pitcairn basalts are characterized by moderate 87Sr/86Sr, low 143Nd/144Nd and 206Pb/204Pb isotopic ratios, and lowest δ26Mg values among OIBs, suggesting a contribution from recycled ancient crustal components (oceanic crust plus sediment). For comparison, we also report the Fe isotope compositions of FOZO-type bas...

An evaluation of M2+ interference correction approaches associated with As and Se in ICP-MS using a multi-day dataset along with ICP-MS/MS/HR-ICP-MS based analysis and hierarchical modeling as a means of assessing bias in fortified drinking waters and single component matrices

Year: 2022
Products: cyclonic quartz spray chamber
Authors: Smith, S;Martin, R;Hanks, N;Creed, P;Kovalcik, K;Wilson, R;Kubachka, K;Brisbin, J;Landero Figueroa, J;Creed, J;
Application: ~
M2+ internal standard ions mimic the drift of other M2+ ions better than M1+. ICP-MS/MS and HR-ICP-MS are used to assess the bias of various M2+ corrections while a Bayesian hierarchical model is used to estimate day to day impacts on the correction....

Analysis of Seventeen Certified Water Reference Materials for Trace and Technology‐Critical Elements

Year: 2022
Products: seaFAST
Authors: Ebeling, A;Zimmermann, T;Klein, O;Irrgeher, J;Pröfrock, D;
Application: Environmental;seawater;
Concentrations of elements in the aquatic environment are a key parameter for various scientific fields such as biogeochemistry, biology and environmental science. Within this context, the scientific community asks for new analytical protocols to be able to quantify more and more elements of the periodic table. Therefore, the requirements for aqueous reference materials have increased drastically. Even though a wide variety of CRMs of different water matrices are available, certified values of many elements (e.g., rare earth elements (REE), technology-critical elements, such as Ga and In, and generally those elements which are not part of current monitoring regulations) do not yet exist. Therefore, the scientific community relies on published elemental concentrations of many CRMs provided by other researchers. Some elements of interest, such as the REE, are well studied and plenty of literature values exist. However, less studied elements, such as Ga and In, are rarely studied. In this...

Analysis of Ti- and Pb-based particles in the aqueous environment of Melbourne (Australia) via single particle ICP-MS

Year: 2022
Products: Spray chamber
Authors: Gonzalez de Vega, R;Lockwood, TE;Xu, X;Gonzalez de Vega, C;Scholz, J;Horstmann, M;Doble, PA;Clases, D;
Application: Environmental;seawater;
The analysis of natural and anthropogenic nanomaterials (NMs) in the environment is challenging and requires methods capable to identify and characterise structures on the nanoscale regarding particle number concentrations (PNCs), elemental composition, size, and mass distributions. In this study, we employed single particle inductively coupled plasma-mass spectrometry (SP ICP-MS) to investigate the occurrence of NMs in the Melbourne area (Australia) across 63 locations. Poisson statistics were used to discriminate between signals from nanoparticulate matter and ionic background. TiO2-based NMs were frequently detected and corresponding NM signals were calibated with an automated data processing platform. Additionally, a method utilising a larger mass bandpass was developed to screen for particulate high-mass elements. This procedure identified Pb-based NMs in various samples. The effects of different environmental matrices consisting of fresh, brackish, or seawater were mitiga...

Analytical feasibility of a new reference material (IRMM-524A Fe metal) for the in situ Fe isotopic analysis of pyrite and ilmenite without matrix effects by femtosecond LA-MC-ICP-MS

Year: 2022
Products: 257 nm Yb fs LA system
Authors: Xu, L;Yang, J;Wang, H;Xie, L;Yang, Y;Huang, C;Wu, S;
Application: ~
Evaluation of the IRMM-524A Fe metal as a primary reference material and natural samples of pyrite and ilmenite as secondary reference materials is presented for the Fe isotopic analysis using femtosecond LA-MC-ICP-MS....

Application of Calcified Structures in Fish as Indicators of Metal Exposure in Freshwater Ecosystems

Year: 2022
Products: HR ICP-MS
Authors: Filipović Marijić, V;Mijošek, T;Dragun, Z;Retzmann, A;Zitek, A;Prohaska, T;Bačić, N;Redžović, Z;Grgić, I;Krasnići, N;Valić, D;Kapetanović, D;Žunić, J;Ivanković, D;Vardić Smrzlić, I;Erk, M;
Application: Tissue;Environmental;
Although there are common and well-established bioindicator organisms and tissues, there is still a need for reliable and sensitive bioindicators in aquatic environments. In the present pilot study, calcified structures in fish were applied as indicators of metal exposure in combination with commonly used fish soft tissues and intestinal parasites, therefore comprising short- and long-term indicators. Patterns of metal accumulation and distribution in soft (muscle, liver) and hard (scales, otoliths) tissues of brown trout (Salmo trutta Linnaeus, 1758) and their intestinal parasites, acanthocephalans (Dentitruncus truttae Sinzar, 1955), from the Krka River influenced by industrial and municipal wastewaters were estimated and compared. Most elements had higher levels in acanthocephalans, scales and liver than muscle and otoliths, possibly reflecting differences in metal uptake routes, tissue function and metabolic activity. Despite the recorded differences in metal contents, all applied ...

Arsenic species in mesopelagic organisms and their fate during aquafeed processing

Year: 2022
Products: SC-4 DX autosampler
Authors: Tibon, J;Amlund, H;Gomez-Delgado, AI;Berntssen, MHG;Silva, MS;Wiech, M;Sloth, JJ;Sele, V;
Application: Total;Speciation;Species;oil;
A responsible harvest of mesopelagic species as aquafeed ingredients has the potential to address the United Nations Sustainable Development Goal 14, which calls for sustainable use of marine resources. Prior to utilization, the levels of undesirable substances need to be examined, and earlier studies on mesopelagic species have reported on total arsenic (As) content. However, the total As content does not give a complete basis for risk assessment since As can occur in different chemical species with varying toxicity. In this work, As speciation was conducted in single-species samples of the five most abundant mesopelagic organisms in Norwegian fjords. In addition, As species were studied in mesopelagic mixed biomass and in the resulting oil and meal feed ingredients after lab-scale feed processing. Water-soluble As species were determined based on ion-exchange high-performance liquid chromatography coupled to inductively coupled plasma mass spectrometry (HPLC-ICP-MS). This was supplem...

Assessing laser ablation multi-collector inductively coupled plasma mass spectrometry as a tool to study archaeological and modern human mobility through strontium isotope analyses of tooth enamel

Year: 2022
Products: NWR193 excimer laser ablation system
Authors: Boethius, A;Ahlström, T;Kielman-Schmitt, M;Kjällquist, M;Larsson, L;
Application: isotope;Laser;
To evaluate the possibility of obtaining detailed individual mobility data from archaeological teeth, the strontium isotope ratios on 28 human teeth from three separate Early-Mid Holocene, Swedish, foraging contexts (Norje Sunnansund, Skateholm and Västerbjers) were analysed through laser ablation. The teeth/individuals have previously been analysed using traditional bulk sampled thermal ionisation mass spectrometry. To validate the conclusions regarding the archaeological teeth, a tooth from a modern man with a known background was also analysed. The result shows that all of the teeth display less than 0.4% discrepancy between the mean values of the laser ablation profiles and the previously published bulk data and 25 (89%) of the teeth display less than a 0.2% discrepancy. By calculating linear and polynomial trendlines for each ablated tooth, it was possible to illustrate a strong correlation for the transition pattern between the measurements when following a chronological sequenc...

Assessing the availability of trace metals including rare earth elements in deep ocean waters of the Clarion Clipperton Zone, NE Pacific: Application of an in situ DGT passive sampling method

Year: 2022
Products: PrepFAST
Authors: Schmidt, K;Paul, S;Achterberg, E;
Application: Dissolved;Speciation;
Geochemical behaviour and bioavailability of trace metals are closely related to their physical fractionation and chemical speciation. The DGT speciation technique allows the challenging assessment of labile concentrations of Mn, Cd, Cu, Ni, V, As, and rare earth elements and yttrium (REY) in ocean waters. In this first deep-water in situ study of DGT lability, we demonstrate the approach in bottom waters of the Clarion Clipperton Zone in the central NE Pacific. In the dissolved fraction (...

Assessing the preservation of biogenic strontium isotope ratios (87 Sr/86 Sr) in the pars petrosa ossis temporalis of unburnt human skeletal remains; a case study from Saba

Year: 2022
Products: PFA-ST MicroFlow nebulizer
Authors: Kootker, LM;Hoogland, M;Laffoon, JE;
Application: isotope;
Strontium isotope (87 Sr/86 Sr) analysis of skeletal remains has become a powerful tool in archaeological studies of human migration and mobility. Owing to its resistance to post-mortem alteration dental enamel is the preferred sampling material used for 87 Sr/86 Sr analysis in bioarchaeological provenance research, although recent studies have demonstrated that cremated bone is also generally resistant to diagenesis. This paper presents the results of a pilot study exploring the potential of unburnt petrous bone (pars petrosa) as a reservoir of biogenic (diagenetically unaltered) strontium, as the otic capsule or bony labyrinth within the petrous bone is extremely dense and is thought to be unable to remodel after early childhood, potentially providing an alternative for dental enamel METHODS: From an individual from a colonial era (18th century) site on the island of Saba in the Caribbean for whom previous enamel 87 Sr/86 Sr results had indicated nonlocal origins, multiple locations ...

Assessment of gadolinium and iodine concentrations in kidney stones and correlation with contrast agent exposure, stone matrix composition, and patient demographic factors

Year: 2022
Products: Spray chamber
Authors: Day, PL;Wermers, M;Pazdernik, V;Bornhorst, J;Jannetto, PJ;
Application: ~
Gadolinium-based contrast agents (GBCAs) and Iodinated contrast media are widely utilized to increase medical imaging sensitivity. With predominant renal elimination, the potential for the incorporation of contrast agent derived gadolinium and iodine into kidney stones remains largely uncharacterized. The study objective was to measure gadolinium and iodine concentrations within kidney stones. Observed elemental concentrations were correlated with prior contrast agent administration, kidney stone composition, age, gender, and smoking status.Kidney stones from 96 patients were analyzed by Fourier Transform Infrared Spectroscopy to determine stone composition. Residual kidney stone material was digested and analyzed by Inductively Coupled Plasma Mass Spectrometry to determine gadolinium and iodine concentrations. Univariable and multivariable lognormal linear regression were performed to study the relationship between kidney stone element concentrations and contrast agent administration,...

Association Between Essential and Non-essential Metals, Body Composition, and Metabolic Syndrome in Adults

Year: 2022
Products: ESI SC-2 DX4
Authors: Ngu, YJ;Skalny, AV;Tinkov, AA;Tsai, CS;Chang, CC;Chuang, YK;Nikolenko, VN;Zotkin, DA;Chiu, CF;Chang, JS;
Application: Blood;
Growing evidence indicates that metal exposure is associated with metabolic syndrome (MetS); however, mixed results have been reported. The aim of this study was to clarify associations of exposure to essential and non-essential metals with body composition and risks of obesity and MetS. Anthropometry and blood biochemistry of metabolic parameters were obtained from 150 middle-aged Taiwanese adults. Plasma metals were assessed using inductively coupled plasma mass spectrometry, and body compositions were measured by a bioelectrical impedance analysis (BIA). The essential metals of copper (Cu), manganese (Mn), and chromium (Cr) were positively correlated with the body fat mass but inversely correlated with the skeletal muscle mass (all p < 0.05). An adjusted logistic regression showed that Mn [odds ratio (OR) = 1.624 (95% confidence interval 1.072, 2.462), p = 0.02] and, to a lesser extent, Cu [OR = 1.501 (0.985, 2.292), p = 0.059] predicted abdominal obesity, whi...