Multiple regulatory authorities worldwide are responsible for ensuring the efficacy and safety of pharmaceutical products. Accurate quantification of potentially toxic and harmful impurities is essential for adhering to regulatory limits for elements like As, Hg, Cd and Pb amongst others. ESI has a range of systems and accessories to automate both sample preparation and measurement, including innovations in bar-code sample reading right at the moment of ICPMS analysis, for complete compliance tracking and ensuring the correct analytical protocols were followed.