SampleSense Clinical for Micro-volume Clinical Samples

Ease of Use

• Automatically trigger ICPMS data acquisition at the correct time
• Built-in error reporting detects and records underfilled or capped vials
• An element added to the carrier allows QC to flag non-sample events

Ultraclean

• Dual rinse station contains surfactant in Rinse 1 and UPW in Rinse 2
• During ICPMS analysis, the sample probe loads and traps surfactant from Rinse 1 and then waits in Rinse 2
• After analysis, both rinses immediately and sequentially clean the system

Robust Operation, Improved Throughput

• Optical sensors in the valve automatically adjust loop load time and inject sample as soon as the loop is full
• Samples load correctly even with partial clogs or other physical problems
• DXCi autocorrecting autosampler reaches the correct vial even if temporarily obstructed
• Low sample consumption – analyze a micro-sample more than once
• Ultra-High throughput is achieved combining SampleSense FAST with a UHT control valve

Precision Uptake

Step 1

Step 2

Step 3

High Speed Rinse

Step 1

Step 2

Step 3

Enhanced Washout

Achieving rapid throughput without sacrificing stability requires excellent washout between samples. The SampleSense Clinical setup utilizes a trapping valve to enhance washout. This valve traps rinse solution in the probe and immediately rinses the loop after the ICPMS data acquisition is complete,using minimal rinse solution while still achieving > 1000x washout after a 100 μg/dL Pb standard.

Pb washout after high calibration standard run 3x in a row. With SampleSense Clinical, washout after one blank is >1000x, and Pb returns fully to baseline after two blanks.

Stability

The SampleSense Clinical was used to analyze 576 bovine blood samples (50x dilution) located in six 96-well microplates in a single analytical run with extremely stable results (<1% RSD). This level of performance is unmatched by any clinical system on the market.

The SampleSense Clinical system is available with a range of autosampler models to suit customer requirements. The 2DXi and 4DXi models can accommodate micro- and microtitre racks in addition to standard sized test tube racks.

Example of a 4DXCi Configuration

Close up of the probe inserted into one of the wells of a 96 well microplate with 2 mL of diluted blood per location, enough to perform a repeat analysis (using a 500 μL sample loop) if required.